Chronic pain can take a heavy toll on quality of life. From limiting mobility to affecting mood, sleep, and daily productivity, unmanaged pain often leaves patients searching for a treatment that provides real, sustained relief. One of the trusted options available in the UK is Longtec; a modified-release (MR) form of oxycodone, designed to deliver powerful pain relief over an extended period.
If you or a loved one have been prescribed Longtec, you may be wondering how it works, why doctors choose it, and what makes it different from other pain medications. This guide breaks down everything you need to know about Longtec and its role in chronic pain management.
What is Longtec?
Longtec is the brand name for oxycodone modified-release (MR) tablets. Unlike immediate-release oxycodone (such as Shortec), which provides quick but short-lived relief, Longtec is designed to release oxycodone gradually into the bloodstream. This allows for consistent pain control over 12 hours, reducing the need for frequent dosing.
The Science Behind Oxycodone MR
Oxycodone belongs to the opioid class of medications, which work by binding to mu-opioid receptors in the brain and spinal cord. These receptors play a key role in processing pain signals. By activating them, oxycodone reduces the perception of pain and alters the emotional response to discomfort.
The modified-release (MR) formulation of Longtec ensures a steady release of the drug, preventing the peaks and troughs of pain relief that often come with short-acting opioids. This makes Longtec particularly suitable for patients with long-term, continuous pain, such as that caused by:
- Osteoarthritis
- Cancer-related pain
- Severe back pain
- Neuropathic pain that has not responded to other treatments
Why Doctors Prescribe Longtec for Chronic Pain
Longtec is generally prescribed when first-line painkillers like paracetamol, ibuprofen, or codeine are no longer effective. Its advantages include:
- Long-lasting relief – each tablet provides around-the-clock control for up to 12 hours.
- Stable dosing – helps patients avoid breakthrough pain between doses.
- Improved sleep quality – consistent pain relief can reduce nighttime awakenings.
- Reduced pill burden – patients need only two doses per day compared to multiple daily doses of short-acting painkillers.
Longtec vs Other Opioids
While there are several opioids available, Longtec stands out for its balance of potency, duration, and flexibility in dosing. Compared with morphine MR, some patients find oxycodone easier to tolerate with fewer gastrointestinal side effects. However, effectiveness and side effect profiles vary from person to person.
How to Take Longtec Safely
- Dosing: Usually taken every 12 hours (morning and evening).
- Swallow whole: Tablets must not be crushed, broken, or chewed, as this destroys the modified-release system and can cause a dangerous dose to be released at once.
- Individualised treatment: Doctors usually start with a low dose and adjust depending on pain levels and tolerance.
Possible Side Effects of Longtec
Like all opioids, Longtec can cause side effects, particularly when starting treatment or adjusting doses. Common ones include:
- Constipation (very common; laxatives are often prescribed alongside)
- Nausea or vomiting
- Drowsiness or dizziness
- Dry mouth
- Sweating
Less common but more serious risks include dependence, tolerance, and respiratory depression. This is why Longtec is prescribed under strict medical supervision.
Longtec and Breakthrough Pain
Sometimes, even with Longtec, patients may experience sudden pain flares. In such cases, doctors may prescribe an immediate-release opioid (e.g., Shortec) alongside Longtec to manage these episodes. This combination allows stable long-term control with flexibility for breakthrough pain.
Longtec Safety: Avoiding Misuse
Because oxycodone is a strong opioid, misuse can lead to serious health risks. Patients should never:
- Exceed the prescribed dose
- Share their medication with others
- Stop Longtec suddenly (tapering under medical guidance is necessary to avoid withdrawal symptoms)
Who Should Not Take Longtec?
Longtec may not be suitable for patients who:
- Have severe breathing problems (such as COPD or asthma)
- Suffer from bowel obstruction or paralytic ileus
- Have untreated depression or a history of substance misuse
- Are allergic to oxycodone or similar opioids
Always consult your healthcare provider before starting or stopping Longtec.
Lifestyle Considerations While on Longtec
Patients on Longtec should adopt supportive lifestyle measures:
- Stay hydrated to help manage constipation.
- Eat a high-fibre diet with fruits, vegetables, and whole grains.
- Avoid alcohol and sedatives unless cleared by a doctor.
- Monitor mood and energy levels, as opioids can sometimes affect mental health.
Alternatives to Longtec
If Longtec does not provide sufficient relief or causes intolerable side effects, alternatives may include:
- Other long-acting opioids (morphine MR, fentanyl patches, buprenorphine patches)
- Adjuvant pain medications (antidepressants, anticonvulsants for nerve pain)
- Non-opioid therapies (physiotherapy, nerve blocks, acupuncture, CBT for pain coping strategies)
The Bottom Line
Longtec (oxycodone MR) is a powerful tool in chronic pain management, offering reliable, long-lasting relief for patients with persistent pain conditions. While it comes with potential side effects and risks, when used under medical supervision, Longtec can help patients regain mobility, improve sleep, and restore quality of life.
FAQs
What is the difference between Longtec and Shortec?
Longtec is a modified-release oxycodone that provides pain relief for 12 hours, while Shortec is immediate-release and works quickly for breakthrough pain but lasts only 4–6 hours.
Can Longtec be used for acute pain?
No, Longtec is not designed for sudden, short-term pain. It is intended for continuous, chronic pain management.
Is Longtec addictive?
Like all opioids, Longtec carries a risk of dependence and should only be used under a doctor’s guidance. Stopping suddenly may cause withdrawal symptoms.
Can I drink alcohol while taking Longtec?
Alcohol increases the sedative effects of Longtec and can be dangerous. It is best to avoid alcohol completely while on this medication.
What should I do if I miss a dose of Longtec?
Take it as soon as you remember, unless it’s close to your next scheduled dose. Do not double up—always follow your doctor’s instructions.